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 Renal Services at The Royal London

Nephrology Services

Taryn Pile, Specialist Registrar in Nephrology at The Royal London started by reminding the meeting of the current interest in the effect of fast food, obesity and school dinners: a greater incidence of type 2 diabetes. People in some ethnic minority groups in the UK were more susceptible and the incidence was increasing in Tower Hamlets. In the USA the incidence of chronic kidney disease from diabetes was now 40% and in the UK it was already 15% and expected to rise.

Taryn explained how the old names to differentiate the development of renal failure had given way to a five-stage system based on glomerular filtration rate (GFR).

Stage

GFR ml/min

 

Managed by

1

>90

Slight kidney damage

Primary care

2

60-89

Mild kidney damage

Primary care

3

30-59

Moderate kidney damage

Nephrology

4

15-29

Severe damage

Nephrology

5

<15

Kidney failure

Nephrology

 

There are several formulae used to assess progress of the disease and these take into account: ethnicity, body weight and creatinine levels. In women the normal level of creatinine is lower than in men. Research done in East Kent indicates only a small proportion of those with kidney disease were known to the renal service and fewer older people and women were referred, yet a creatinine of 150 in a woman indicated more severe kidney disease than for a similar level in a man. Late referrals  may already have a low haemoglobin, and potassium levels that are out of control. Research has also indicated better survival if a patient was referred before haemodialysis was required.

The BTL service now takes patients over the age of 65 years for haemodialysis if they are fit and strong. There were about 600 patients receiving haemodialysis, mainly in hospital units. Peritoneal dialysis being used for home treatments. There was a National Service Framework to help achieve a consistent approach across the NHS. The laboratories at BTL now provide a GFR when a GP requests blood creatinine levels, so they can start treating the cause, metabolic imbalance and cardiovascular risks. The aim is to achieve a blood pressure of 130/80, or even 125/75, in people with diabetes. Nurse consultants are now working with GP practices in the local Primary Care Trust to help develop screening (blood  and urine dip-stick tests) for at-risk patient groups.

Nephrologists help identify the cause of renal damage and to prevent a decline to renal failure by reducing proteinuria and using ACE inhibitors and angiotensin receptor blockers. One of the challenges was the increasing erythropoietin deficiency that develops when the peritubular cells become damaged. The resulting anemia can lead on to cardiac damage. Treatment with EPO can be by sub-cutaeous injection administered by a 'pen' or standard syringe.  Renal bone disease can be a further problem, with some effective but expensive medications.

People with Stage 4 or 5 chronic kidney disease are referred to a Low [Creatinine] Clearance Clinic for multi-disciplinary assessment and to agree a long-term plan for treatment. Some patients decide not to receive renal replacement therapy and there is a specialist nurse to support those in end-stage renal failure. In the first nine months of this service about 30 patients were referred for this support, so it is too early to evaluate the service. Patients who opt for peritoneal dialysis receive intensive training and support. Those who choose to receive haemdialysis need early referral to the surgeons to have a fistula created or for transplant assessment. Each form of treatment has advantages and disadvantage particularly for family and social life. There is a high incidence of depression. Dialysis requires careful management of the diet and a low fluid intake: foods usually advised for diabetics may have to be avoided for renal patients.

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Page last updated by DEB on 10/10/2005